UCI Scientists Develop Humanized Mice For Studying Alzheimer’s Disease

Feb 27, 2020

UC Irvine scientists have come up with a method to integrate human brain immune cells in mice, which could give medical researchers the information they need to understand and ultimately develop new ways to combat Alzheimer’s.

Neurology and behavior associate professor Mathew Blurton-Jones says that microglia, a type of brain cell, can play a crucial role in how Alzheimer’s develops and progresses. He explains that there are 40-plus genes that are linked to the neurodegenerative disease and most of them are found within the microglia. Up until now, scientists have only been able to study them in end-stage Alzheimer’s in labs or post-mortem.

The chimeric model uses mice for human brain cells via special induced pluripotent stem cells donated by human patients. The stem cells were coaxed into turning into microglia which were then implanted in genetically modified mice.

The new chimeric model may finally unlock the secrets of immune cells in terms of brain development and in treating many types of neurological disorders.

To your health,

The Healing Miracle Team

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