New Findings Reveal Positive Outcome For Gut Issues Later In Life
Helsinki University researchers have recently found out the reason why our intestinal epithelium’s capacity to regenerate declines over time.
What’s more, the same team has discovered that targeting a specific stem-cell inhibiting enzyme unlocks the rejuvenative properties of aged intestines.
The findings can potentially open up new treatment involving age-related gastrointestinal problems, minimize the after-affects of cancer treatment, promote recovery, and reduce the costs of healthcare, especially for the aged society.
Pekka Katajisto, Karolinka Institute and Helsinki University Associate Professor and principal investigator, says that the study focuses on the value of cellular interactions, where a cell alteration resulted in an aging factor secretion, one that could be targeted using modern medicine. Furthermore, Katajisto has mentioned that the findings could open up multiple intervention points that are more attractive than conventional treatment.
Reduced tissue renewal caused by aging is inherently difficult to dose. Researchers believe that targeting Notum, an inhibitor, can open up new avenues of therapeutic, regenerative therapies in the aged society. Aside from the possibility of targeting Notum, changes in diet can further reduce Notum, thereby facilitating faster tissue repair and renewal.
In the study, organoid culture methods revealed the fact that the reason why stem cells in the old intestine were not functioning was because of neighboring cells called Paneth cells.
Nalle Pentimikko, Helsinki University PhD candidate and lead author, mentioned that modern technology has allowed the team to examine and determine which cell types were responsible for the tissue decline.
In a normal intestinal epithelium, stem cell renewal is mostly done via Wnt-signaling pathway activity. With the process of aging, Paneth cells start secreting Notum, a Wnt-inhibitor, which de-activates Wnt-ligands within stem cells, reducing their regenerative abilities.
Pharmacologic inhibition of the said Notum promoted activity and recovery in old animals via stem cell rejuvenation. This was done after chemotherapeutic drug treatment was completed, with known side effects in the gut.
To your health,
The Healing Miracle Team
Did you enjoy this article?
Share your own experiences below!
Researchers at the Dental Medicine School in UConn used the latest in technology to observe real-time cellular communication, a process that can eventually lead us to understand cell secretion dynamics and the mechanism of tissue repair. Assistant professor Kshitiz...
Heart health and function, brain function, metabolism, bone health. You likely agree those are extremely vital processes in your body, right? Well, there’s a nutrient you’ve probably never heard of that is responsible for each of those processes, and yet some experts...
A recent study revealed harmful results that come with the use of e-cigarette and flavored e-cigarette liquids. The study involved the use of stem cells in discovering negative repercussions that come with e-liquids concerning cardiovascular diseases. Cinnamon and...