Stem Cell Protein Secretions Recorded in Real Time

Aug 24, 2019

Researchers at the Dental Medicine School in UConn used the latest in technology to observe real-time cellular communication, a process that can eventually lead us to understand cell secretion dynamics and the mechanism of tissue repair.

Assistant professor Kshitiz Gupta and post-doctoral fellow Yashir Suhail of Biomedical Engineering have arrived at a new technology platform. This technology is the world’s first equipment that allows scientists to record cell communication in real time, which potentially opens up new possibilities for cell biology, including stem cell therapy.

The study was published in the National Academy of Sciences’ Proceedings journal.

Cells have an innate ability to communicate with each other constantly. Unlike humans, cells receive and send messages via protein secretion and behavioral changes. When we listen to people conversing with each other, we understand the words and the flow of it. But in cell communication, key factors were not known until now.

Cell communication plays a vital part in maintaining most bodily functions. Moreover, it helps us respond to external stimuli, such as injuries and ailments. Current equipment can only show a snapshot of protein secretions, which Kshitiz describes as ‘similar to seeing the words in sentences but not knowing the tone, inflection and placement’. The assistant professor also added that before, the language that we have in regards to cell communication was very limited and therefore did not encapsulate the messages and its complexity.

The UConn researchers utilized computer modeling and microfluidics to create a platform that could record cell conversation in-depth. The new technology now allows scientists to determine the tone, words and messages within the intercellular setting.

Kshitiz and the team worked on stem cells collected from bone marrow as a potential treatment for myocardial infarction. The stem cell’s protein secretion and gradual changes were recorded with time using the platform. The study was funded by both the National Cancer Institute and the American Heart Association.

The resulting data led to a new discovery, one that found that an injury may be aided without using stem cells. The ‘conversations’ between cells gave the researchers the ability to copy the behavior of stem cells.

On a closer look, the UConn team gathered that stem cells have the flexibility to change ‘behavior’ depending on the present injury. Moreover, they discovered that stem cells only change when they find injured tissue.

Kshitiz adds that a ‘cell-less’ treatment can be made possible by copying the stem cell’s reaction when they see an injury in the form of a protein cocktail that can regenerate cardiac tissue. In turn, cell-less therapy can make things simpler by eliminating complications that come with stem cell transplantation.

Suhail says that the team’s findings have solved a fundamental problem that’s been plaguing systems biology for the longest time. The technological platform invariably opens up new possibilities and lines of inquiry by decoding the way cells communicate with each other at a level that was previously unforeseeable.

Stem cell therapy and ‘cell-less’ treatments are branching out and advancing, thanks to the new communication platform discovered by assistant professor Kshitiz Gupta, postdoctoral fellow Yashir Suhail, and the research team at UConn. 

 

To your health,

The Healing Miracle Team

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25 Comments

  1. Ronald Nielsen

    it would replace drug interdiction if im getting the correct information here….

    Reply
    • Faasegi Caldwell

      yes, very much

      Reply
  2. ELANA SEGER

    Any local locations in Denver Colorado?

    Reply
    • THM Team

      A network of stem cell specialists is available to provide more personalized answers – http://www.StemCellHotline.net/today. They can connect you with a stem cell specialist in your area to answer the question, “Are Stem Cells Right For You?” and to help you find the solution that works best for you. Additionally, a simple Google search (“stem cell clinic” + your region) will pull up a list of treatment centers near you. Always consult your own health care provider to ensure your care is in the best possible hands.

      Reply
  3. arthur

    Fantastic what next.

    Reply
  4. Diane Mardison-James

    Truly amazing…

    Congratulations as you pioneer into new discoveries
    Of stem cell therapy…

    Reply
  5. Madeleine

    Brilliant news Mother Nature never fails to amaze me.

    Reply
  6. Gonzalo Ojeda

    Dear Sirs,
    Can cartilage be recovered with stem cells?
    Regards

    Reply
    • THM Team

      While we are unable to make specific recommendations about your personal health, a network of stem cell specialists is available to provide more personalized answers – http://www.StemCellHotline.net/today. They can connect you with a stem cell specialist in your area to answer the question, “Are Stem Cells Right For You?” and to help you find the solution that works best for you.

      Reply
  7. Margaret Lapierre

    This is becoming very exciting and there’s a strong sense of regenerative medicine becoming so important to the healing of many ills. Our personal desire to see success has to do with advances to help people with Parkinson’s.

    Reply
  8. Alice

    I have a motor neuron disease. Can stem cell therapy help me?

    Reply
    • THM Team

      While we are unable to make specific recommendations about your personal health, a network of stem cell specialists is available to provide more personalized answers – http://www.StemCellHotline.net/today. They can connect you with a stem cell specialist in your area to answer the question, “Are Stem Cells Right For You?” and to help you find the solution that works best for you.

      Reply
  9. Bev

    received stem cells for pain & neurologic purposes & do feel better but still healing from it. Thanks for the opportunity since our health care system has no alternatives other then passive exercises/physical therapy. Even pain or sleep issues are ignored as you get older.

    Reply
  10. Barry

    Thank you very much for the update on Stem Cell Theropy which I think will be able to help our ageing population in the near future.

    Reply
  11. Norm

    Are these stem cells working on ccndl and mdm2 tumor Ampullary cancer . I’m in desperate need to find out yesterday .

    Reply
  12. Jack Morrison

    I thought, by the title, we would actually see the fill.m. I was mistaken.

    Reply
  13. Kathy Miller

    I wish this therapy was available near me. I would love to have it used to repair or help heal my back and hip!

    Reply
    • THM Team

      A network of stem cell specialists is available to provide more personalized answers – http://www.StemCellHotline.net/today. They can connect you with a stem cell specialist in your area to answer the question, “Are Stem Cells Right For You?” and to help you find the solution that works best for you. Additionally, a simple Google search (“stem cell clinic” + your region) will pull up a list of treatment centers near you. Always consult your own health care provider to ensure your care is in the best possible hands.

      Reply
  14. Joel Kugler

    I need to find a facility that does stem cells for my lungs as close to me as possible, i live in the Denver, Co. area, need help ASAP

    Reply
    • THM Team

      A network of stem cell specialists is available to provide more personalized answers – http://www.StemCellHotline.net/today. They can connect you with a stem cell specialist in your area to answer the question, “Are Stem Cells Right For You?” and to help you find the solution that works best for you. Additionally, a simple Google search (“stem cell clinic” + your region) will pull up a list of treatment centers near you. Always consult your own health care provider to ensure your care is in the best possible hands.

      Reply
  15. stewart

    Yes thank you. I will look more closely at the reseasrch

    Reply
  16. Carol Handy

    What I need to know, is what, if any, study is being pursued as to stem cell treatment for the forms of COPD, especially Idiopathic Pulmonary Fibrosis. For those of us who are, for one reason or another, not eligible for lung transplant, there is no hope of cure at the present time, and the medications available are only minimally helpful, never resulting in restorative cure.

    Reply
    • THM Team

      “While there is a great deal of ongoing research into the benefits of stem cell therapy for various conditions, injuries and diseases, The Healing Miracle has limited information readily available on that particular topic. We recommend:

      · searching the internet using a simple Google search to find recent articles, studies and research (ie “”stem cell + _________””)

      · join the Facebook group Stem Cells 101 and ask that community to share their experience about this condition https://www.facebook.com/groups/stemcells101/

      · visit the blog site http://www.thehealingmiracle.com to review the articles there

      · contact http://www.StemCellHotline.net/today to be connected with a stem cell specialist who may have more information relating to this particular condition

      Reply
  17. Angela

    hi

    i want to know if this can help autistic patients

    Reply
    • THM Team

      While there is a great deal of ongoing research into the benefits of stem cell therapy for various conditions, injuries and diseases, The Healing Miracle has limited information readily available on that particular topic. We recommend:

      · searching the internet using a simple Google search to find recent articles, studies and research (ie “”stem cell + _________””)

      · join the Facebook group Stem Cells 101 and ask that community to share their experience about this condition https://www.facebook.com/groups/stemcells101/

      · visit the blog site http://www.thehealingmiracle.com to review the articles there

      · contact http://www.StemCellHotline.net/today to be connected with a stem cell specialist who may have more information relating to this particular condition

      Reply

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